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The pre-clinical study of small animals is a vital stage in the discovery and development of new drugs and in investigating biological processes and mechanisms at all levels, from molecular to whole body. With the appearance of dedicated imaging systems for small animals, researchers can more easily and effectively monitor disease processes, and better understand the effects of new drug treatments. The main advantages of most imaging systems are that they enable the researcher to observe the animal in-vivo with high resolution, in real time, continuously and non-invasively.

Using MRI equipment for pre-clinical imaging significantly improves the drug discovery process, providing new continuous information and shortening the development period, thus providing bio-medical and economic advantages. Unlike other imaging modalities, MRI enables monitoring the same animal over time. With MR specific contrast agents, researchers can monitor events in-vivo and in-vitro at the molecular level. Improving the quality of the research is expected to shorten discovery and development time and lower the overall R&D costs associated with new drugs. Understanding new biological events and mechanisms can push forward our knowledge and offer new diagnosis and treatment options.

Magnetic Resonance Imaging has high spatial resolution, high sensitivity, 3D imaging capability and non-ionizing radiation. It can image objects at any selected plane and has superior performance in soft tissues. The properties of MRI are core to any pre-clinical study, covering many research fields and providing high quality, non-invasive quantitative and visual information not achievable by any other technology.

Aspect is now offering a new MRI system designed and developed specifically for pre-clinical applications and to accommodate today's demanding user needs. The system innovative features provide clear advantages in many aspects: performance, cost, operation, maintenance, mobility and simplicity.

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Bringing dedicated MRI to the clinician's desk

ASPECT plans to introduce its high performance, medical grade 1-1.5 Tesla, desktop size MRI systems for human clinical extremities applications. The system's unique properties enable placing it in environments where MRI scans are impossible today. ASPECT's system can be placed:

  • in physicians' clinics and offices
  • in points of care
  • next to patient's bed, in the ER, or in any other place at the hospital or medical center

The system design is planned to be optimized for the examined organ. Furthermore, since the effective performance is equivalent to higher field clinical MRI systems, ASPECT's system performance would provide high quality images for better diagnosis and treatment planning of human diseases.

Low ownership and operational costs, small footprint requirement, easy installation and friendly operation would make the system ideal for clinical extremities imaging. Its innovative features would open the door for many clinicians and patients to benefit from the qualities of non-invasive and sensitive MR imaging. Both existing applications limited today by their low cost-effectiveness and new applications are expected to be available and easily accessible with ASPECT’s innovative clinical systems.

Possible applications are:

  • Carpal Tunnel Syndrome and wrist diagnosis
  • Monitoring and treatment assessment of bone diseases, such as osteoporosis and performing a non-invasive bone biopsy
  • Cardiovascular Flow Mediated Dilation assessment
  • Hand and foot diagnosis and real-time surgery


 

  
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